Liquid Biopsy to Gain Footholds in Clinical Treatments of Cancer Patients

Liquid Biopsy Market

In this past year liquid biopsy technologies earned first solid footholds in the clinical care of cancer patients, while researchers turned their eyes to deliver utility in other niches as well as funders provided support behind companies who wish to transform these approaches to initial detection and prevention of cancer.

In the late 2016 recognised the 1st US FDA approval of tumor mutation assay based on blood, as friendly diagnostic in lung cancer for AstraZeneca’s Tagrisso. However, it was more than the previous year, clinicians really initiated to prove an acceptance of liquid biopsy in the care of lung cancer patients, launching this niche as a proving ground for the technology.

As the 1st step in clinical acceptance of non-invasive tumor tests, non-small cell lung cancer makes sense. Getting tissues from lung cancer patients those are at late-stage, leads to major risks and possibly equally as essential, there are number of therapies that are molecularly targeted, which are now available for such subset of cancer that all need the diagnosis of genomic mutations to notify its use.

Early oppositions to liquid biopsy concentrated on the information that had exhibited lack of parallelism between genetic features innovated in flowing cell-free DNA and those in the samples of tumor tissue in the same patient. Several times liquid biopsy failed to detect mutations to be present in tumor tissue. Past these concerns, clinicians now-a-days appear to be moving, recognizing at least in NSCLC, benefits of being able to test patients those, who can’t be biopsied or those require a rapid result balances the drawbacks of mistaken or missed mutation.

Practice guidelines particularly mentioned liquid biopsy as a choice for the first time, with National Comprehensive Cancer Network particularly stating plasma biopsy need to be taken into consideration in NSCLC if tissue biopsy is not possible. However, discussion in the scientific meetings during the past year has suggested that in practice, cancer tests based on the blood are increasingly being ordered not just for patients, whom biopsy is impossible, as stated by language of the FDA in regard to Roche Cobas assay, however, also as a quick diagnostic before or alongside testing based on tissue.

Liquid biopsy firm Biocept, for instance introduced a marketing campaign over the year attempt to encourage clinicians to mandate a liquid test along with tissue identification at the time of analysis as a typical practice. Researchers also started to share some of the first direct evidence in the year 2017 that liquid biopsy testing and subsequent targeted therapy enhance patient outcomes in a way which looks consistent with whatever seen in pivotal pharmaceuticals trials, which utilized genetic testing based on tissue.

Despite the statement that the Roche EGFR assay is an only liquid biopsy test yet accepted by FDA, clinicians and researchers reported in the year 2017 – they are implementing other approaches, which they believe either cross-examine EGFR more sensitively or that offer broader profiling of various genes or mutations.

During the annual meeting of Association for Molecular Pathology, representative from Cancer Genetics, discussed the acceptance of ThermoFisher’s Oncoming Lung cfDNA assay that delivers the backbone for a test CGI calls.

The Market for Liquid Biopsy to Gain Momentum

Apropos a Future Market Insights’ study, the market for liquid biopsy to expand at exponential growth rate during 2017 – 2027, to reach valuation more than US$ 3,130 Mn by 2027-end.

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About Sabyasachi Ghosh 35 Articles
Sabyasachi Ghosh is an experienced market research analyst and consultant, with over six years of experience in end-to-end project management. He has worked at numerous leadership positions and has a vast experience of compiling high-quality market research reports. Sabyasachi is an authoritative voice in the market research sector, and has been cited in top industry publications. He is a travel junkie, and loves to travel far and wide with his friends.