Los Angeles Children’s Hospital Employs Scientific Research to Devise Affordable Therapies for Treating Brain Tumors

Multi-institutional academics join the hospital’s clinical investigators to probe medical studies that identify essential biomarkers for improving pediatric ependymoma therapies.

Development of affordable and less aggressive treatment therapies for children with brain tumors is being highly prioritized by medical institutions and research organizations across the globe. Extensive research on medical sciences and a characteristic approach paves way towards development of therapies that are less expensive yet effective. On a similar note, science and medical academics from the University of Michigan have reportedly collaborated with the Children’s Hospital Los Angeles for formulation of new therapies that will treat children suffering from brain tumors. Clinical tests of newly developed therapies will define the fate of the city’s ailing children, particularly the ones suffering from ependymomas.

Investigations led by a group of scientific researchers from multiple institutions were conducted at Los Angeles’ Children’s Hospital for assessment of a tool that aids treatment of pediatric brain tumors such as ependymomas. Medical science studies conducted in this research have helped them identify an inexpensive and methodical tool for prognosis of ependymoma treatments. Demonstration of epigenetic mechanism behind ependymoma tumors has created opportunities for development of innovative therapeutic alternatives. Immunohistochemical staining conducted in the research has resulted in detection of a biomarker called H3K27me3. Practicality and efficiency of this biomarker is slated to transition the status of medical treatments that cure childhood posterior fossa ependymomas.

Medical sciences illustrate the presence of ependymoma tumors in the hind brain of children. Identifying a surrogate molecular biomarker was crucial as tumor grade and other biomarkers known to medical professionals were not linking aptly with the tumor’s upshots. The detection of H3K27me3 has become ground-breaking in pathological medical science since it is being rendered as a vital tool for assorting ependymoma patients that exhibit potential for benefiting from epigenetic therapies. Since genomic sequencing failed to disclose mutations occurring in the tumor and could not ascertain the source of ependymoma tumor, scientific researchers who participated in this study explored modifications of histone 3, a chromatin-link protein component around which the DNA strands are coiled. A scientific feat along these lines is expected to help children suffering from brain tumors in Los Angeles, and in rest parts of the world.

About Siddhesh Asalekar 26 Articles
Siddhesh Asalekar is an independent columnist and writer, covering latest news and market updates on a variety of industrial verticals. With over three years of experience in reporting cutting-edge stories & events, Siddhesh continues to quench his undying thirst of being a competent expert. The budding writer devotes his downtime indulging into Netflix shows and gaming.